| Autor: |
Ross, W. M., Koerbling, M., Nothdurft, W., Fliedner, T. M. |
| Zdroj: |
Experimental Biology and Medicine; February 1978, Vol. 157 Issue: 2 p301-305, 5p |
| Abstrakt: |
Intravenous administration of 10 mg or 15 mg dextran sulfate per kg body weight into dogs results in a marked increase of CFUc in the blood within 3 hr and, to a considerably lesser extent, of mononuclear leukocytes (MNC). The increase after the higher dose is more than tenfold, from less than 200 CFUc/ml blood to about 2000 CFUc/ml, within 3-5 hr; the CFUc gradually decrease thereafter to control levels several hours later. On the other hand, the MNC population experiences a two- to threefold increase which is maintained for several hours. The increase in CFUc after 10 mg/kg is less than after 15 mg/kg, indicating dose-dependence.There is also a cumulative increase observed in the CFUc concentration in blood after repeated injections of dextran sulfate; there is no significant alteration in PMN and MNC levels and there is a slight decrease in the hematocrit and in the thrombocyte level.The mechanism responsible for this phenomenon has not yet been clarified. Due to the probable action of polyanions on cell membranes affecting their adherence capabilities, one may consider both an increased rate of release of CFUc from a marginal or extravascular pool into the blood, as well as a prolongation of the CFUc blood transit time as being contributing factors to the observed blood CFUc increase. |
| Databáze: |
Supplemental Index |
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