| Autor: |
Collisson, Ellen Whited, Andersson, Birger, Lamon, E. W. |
| Zdroj: |
Experimental Biology and Medicine; October 1979, Vol. 162 Issue: 1 p194-198, 5p |
| Abstrakt: |
Immunization of mice with TNP coupled to ORBC resulted in a TNP-specific antibody response. TNP-specific direct and indirect PFC in the spleens reached a maximum level 5 days after injection. Passively administered anticarrier antibodies injected with the hapten-carrier conjugates were found to modulate the primary PFC response to hapten. Three days after injection, both classes of carrier-specific antibody induced potentiation of hapten-specific direct and indirect PFC. On Day 5, however, IgM and IgG had opposite effects on the TNP-specific response. Carrier-specific IgM produced a three- to fourfold increase in both direct and indirect hapten-specific PFC over animals injected with the hapten-carrier conjugates alone. In contrast, carrier-specific IgG, at relatively high concentrations, suppressed the hapten-specific indirect PFC but had little effect on direct hapten-specific PFC. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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