Hyperactivity of Metachloridine against Plasmodium gallinaceumin Chicks Maintained on a Purified Diet.∗

Autor: Taylor, D. Jane, Greenberg, Joseph
Zdroj: Experimental Biology and Medicine; November 1955, Vol. 90 Issue: 2 p551-554, 4p
Abstrakt: 1. The erythrocytic form of the malarial parasite Plasmodium gallinaceumwas found to grow at a comparable rate in chicks fed either a purified diet (C-2) or a commercial stock diet. The antimalarial activity of 7 compounds was approximately the same in parasitized chicks fed either of the above diets, while sulfadiazine and metachlor-idine exhibited a marked increase in effectiveness in those chicks fed the C-2 diet. 2. The hyperactivity of metachloridine in chicks fed the C-2 diet was reversed almost completely when this diet contained 41% soybean meal. Neither the fatty nor protein fractions of soybeans, nor several other dietary nutrients appeared to contain significant amounts of the inhibitor.
Databáze: Supplemental Index