| Abstrakt: |
Sodium citrate injected into rabbits in amounts ranging from 9 μMoles to 150 μMoles produces a transient, significant in vivoinhibition of the plasma deoxyribonuclease. Injection of heterologous DNA into rabbits induces a prolonged decrease in total serum cholesterol. 30 μMoles of citrate and 0.1 mg DNA, injected together, are quantitatively as effective as 3 mg DNA in altering the serum cholesterol regulation. The citrate-induced deoxyribonuclease inhibition increased the physiologic activity of the injected DNA as much as 30-fold. |
