Growth and Respiration of Monolayer Cell Cultures of Chick Embryo Heart and Skeletal Muscle: Action of Malathion and Malaoxon∗

Autor: Wilson, B. W., Stinnett, H. O.
Zdroj: Experimental Biology and Medicine; January 1969, Vol. 130 Issue: 1 p30-34, 5p
Abstrakt: The respiration of chick embryo heart and pectoral muscle cell cultures was determined using a polarographic respiration chamber designed specifically to measure the oxygen consumption of monolayers of cells. Heart cultures had a mean respiration rate of 215 ± 84 mμmoles O2/hr/106cells; pectoral muscle cultures had a mean respiration rate of 163 ± 46 mμmoles Oa/hr/106cells. Malathion 3 × 10−4Mreduced the respiration of pectoral muscle cultures to 26% of normal and the respiration of heart cultures to 50% of normal. Malaoxon 3 × 10−4Mhad no effect upon the respiration of either cell type. Growth studies indicated that malathion was more toxic than malaoxon to the growth of both cell types.
Databáze: Supplemental Index