| Autor: |
Guthrie, S. D., Murphy, Q. R. |
| Zdroj: |
Experimental Biology and Medicine; November 1973, Vol. 144 Issue: 2 p581-586, 6p |
| Abstrakt: |
The effect of beta blockade on epinephrine induced hepatic K+mobilization was examined by measuring hepatic arteriovenous K+differences and splanchnic blood flow following epinephrine injections before and after administration of propranolol.The results demonstrated that alterations in splanchnic blood flow significantly modify the epinephrine-induced systemic hyperkalemic response either by reducing liver perfusion during the period of hepatic K+efflux or by diminishing the amount of epinephrine delivered to that organ. It was evident that using systemic arterial K+concentrations as an index of hepatic K+movements is inadvisable. To assess adequately the ability of an adrenergic agonist to mobilize hepatic K+, or the ability of an antagonist to disrupt that process, measurements of hepatic effluent K+and splanchnic blood flow must be made. The present experiments do not support the contention that the adrenergically-induced movement of K+into or out of the liver depends upon the activation of beta receptors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
