| Autor: |
Waxler, Samuel H., Brecher, George, Beal, Stuart L. |
| Zdroj: |
Experimental Biology and Medicine; November 1979, Vol. 162 Issue: 2 p365-368, 4p |
| Abstrakt: |
C3H/HeJ mice show a high incidence of spontaneously occurring mammary tumors. Mice made experimentally obese were observed to have an earlier appearance and a greater incidence of tumors than were the normal-weight mice. A fatenriched diet increased the observed tumor incidence in normal-weight mice to about that of obese mice given a regular diet, while a fat-enriched diet further enhanced the already augmented observed yield of mammary tumors in the obese mice given a regular diet. Statistical analysis supported the dependence of tumor incidence and appearance time on the type of diet. The calories consumed by normal mice on a fat-enriched diet was considerably below that of obese mice on a regular diet, yet produced about the same tumor incidence. A specific effect of the fat-enriched diet is suggested.High caloric diets, particularly those modified to include a high portion of fat, have been reported to promote or enhance the occurrence of several types of tumors in various species of animals (1–3). Mice, force-fed to enhance weight gains, show an increase in tumors. In contrast, dietary restriction delayed or inhibited the formation of spontaneously occurring or experimentally induced tumors (4–6). In the present study virgin female mice were made obese by a single injection of goldthioglucose (7–16). These mice reached weights of 50–60 g compared to controls of 25–30 g and showed an increased tendency to tumor formation. This was evidenced by an earlier appearance and a greater incidence of spontaneously occurring mammary tumors than found in control mice (8–10). The excess weight gain has been shown to be due to increased food intake and to primarily represent adipose tissue (11). These mice can mobilize the excess fat during starvation and regain it on ad libitumrefeeding (11). |
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