| Autor: |
Ducoff, Howard S., Neal, William B., Straube, Robert L., Jacobson, Leon O., Brues, Austin M. |
| Zdroj: |
Experimental Biology and Medicine; December 1948, Vol. 69 Issue: 3 p548-554, 7p |
| Abstrakt: |
1. Arsenic excretion was studied in man, rats, and rabbits. Less than 10% of the excreted arsenic is found in feces in any of these species; rats have by far the slowest rate of excretion.2. Data are given for arsenic distribution in various organs in man, the rat, the rabbit, and 2 strains of mouse.3. The degree of individual variation within each species was very great; in contrast to man and to other animals studied, the rat retains most of the injected dose in the blood for a considerable length of time.4. The ratio of arsenic concentration in kidney, liver, and spleen of healthy inbred mice was found to be fairly constant for a given time after administration, and this ratio is suggested as a criterion for effects of various types of treatment.5. Using this ratio as criterion, it was found that arsenic distribution is altered by the presence of transplanted tumors.6. Factors changing arsenic distribution are discussed in relation to effects on levels of sulfhydryl-containing substances. |
| Databáze: |
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