Obsah

Metabolism of Thiamine-S35in the Rabbit.∗

Autor: Verrett, M. Jacqueline, Cerecedo, Leopold R.
Zdroj: Experimental Biology and Medicine; July 1958, Vol. 98 Issue: 3 p509-513, 5p
Abstrakt: The fate of thiamine, labeled with sulfur-35 in the thiazole moiety, has been studied in rabbits after oral and parenteral administration of doses in the physiological range. Analyses of the urinary and fecal sulfur fractions for 4 to six 24-hour periods following administration of radiovitamin, gave average total recovery of radiosulfur of 77% after administration by stomach tube, 86% after intramuscular injection, and 54% after intravenous injection. When oral dose of radiovitamin was followed 6 hours later by intramuscular injection of a 20-fold larger dose of non-radioactive thiamine, an additional 17% of radiosulfur was recovered in urine. In all cases, the neutral sulfur fraction of urine contained more than 50% of the recovered radiosulfur, and the greater portion of this was excreted in the first 24-hour period following administration of radiovitamin. Isolation of main metabolites following oral administration indicates that unchanged thiamine-S35and thiazole S35moiety together account for approximately 95% of radiosulfur of the neutral sulfur fraction in the first 24-hour period, and are excreted in a ratio of 2 : 1, respectively.
Databáze: Supplemental Index
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