| Autor: |
Miller, Dennis W., Allen, D. O. |
| Zdroj: |
Experimental Biology and Medicine; March 1971, Vol. 136 Issue: 3 p715-718, 4p |
| Abstrakt: |
The antilipolytic activity of the beta-adrenergic blocking drug, 4-(2-hydroxy-3-isopropylaminopropoxy) acetanilide (practolol), was examined using the isolated fat cell preparation. The compound was found to be a competitive inhibitor of hormone-stimulated lipolysis with low intrinsic activity. As determined by pA2values the compound was 80-100 times less potent than propranolol. In contrast to propranolol, practolol did not inhibit the lipolytic response to dibutyryl cyclic AMP nor ACTH. Practolol also failed to inhibit glucose oxidation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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