Distribution of Antibodies to Native DNA, Single-Stranded DNA, and Double-Stranded RNA in Mouse Serums1

Autor: Thoburn, Robert, Koffler, David, Kunkel, Henry G.
Zdroj: Experimental Biology and Medicine; March 1971, Vol. 136 Issue: 3 p711-714, 4p
Abstrakt: Hemagglutinating antibodies to native DNA were found to occur selectively in NZB/W mice and rarely in other strains. In contrast, antibodies to single-stranded DNA and double-stranded RNA have a more widespread distribution. They occur in NZB and NZB/W mice as well as other strains of mice. Poly A·poly U and poly I·poly C are shown to be immunogenic in mice without the use of Freund's adjuvant or in vitrocoupling to a protein carrier.
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