| Autor: |
Mishra, L. C., Mead, J. A. R. |
| Zdroj: |
Experimental Biology and Medicine; November 1971, Vol. 138 Issue: 2 p709-711, 3p |
| Abstrakt: |
A relationship has been noted between the antitumor activity of H4HF and its effect on incorporation of formate and orotate into DNA of organs of mice bearing advanced methotrexate-sensitive (L1210) and -resistant (L1210/FR-8) leukemia after daily treatment with H4HF for 4 days. Both formate and orotate uptake into DNA was markedly inhibited in organs of mice bearing L1210/FR-8 leukemia, but not in mice bearing L1210 leukemia. Single doses did not cause demonstrable inhibition of DNA synthesis in organs of mice bearing either of the tumor lines. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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