| Autor: |
Mendes, Francisco R.S., Silva, Francisca G.E., Sousa, Erlânio O., Rodrigues, Fabíola F.G., Costa, José G.M., Monte, Francisco J.Q., Lemos, Telma L.G., Assunção, João C.C. |
| Zdroj: |
Journal of Essential Oil Research; May 2015, Vol. 27 Issue: 3 p259-263, 5p |
| Abstrakt: |
Essential oils are new natural medicines, which have been studied extensively in recent years. In this paper, the chemical composition of the essential oil from Alpinia zerumbetleaves and its ability to modulate the activity of aminoglycoside antibiotics is reported. The essential oil was extracted by hydrodistillation and analyzed by gas chromatography (GC) and GC–mass spectrometry (GC/MS). The antibacterial activity of the essential oil alone or in association with aminoglycosides was determined by a microdilution test against twelve strains (standards and multi-resistant clinical isolates obtained from sputum and wounds), seven Gram negative and five Gram positive. The major components identified by GC/MS were 4-terpineol (32.9 ± 4.0%), 1,8-cineole (21.4 ± 1.2%), γ-terpinolene (10.0 ± 1.8%) and sabinene (7.1 ± 4.6%), with a strong predominance of monoterpenes. The results indicated that the multi-resistant clinical isolates Staphylococcus aureus358 and Escherichia coli27 were more sensitive to the essential oil, exhibiting minimum inhibitory concentrations (MICs) of 32 and 128 μg/mL, respectively. The essential oil was capable of enhancing the antimicrobial activity of aminoglycosides against all strains tested, except for S. aureus358. Very significant reductions in the MICs of the antibiotics were found, with a 94% decrease in MIC of neomycin against Klebsiella pneumoniaeATCC 10031. The results obtained indicate that the A. zerumbetessential oil has a significant synergistic antibiotic effect when combined with aminoglycosides, demonstrating that its constituents may act as potentiators of the antibiotic activity of aminoglycosides. |
| Databáze: |
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