| Autor: |
Chandra Shekhar, Adimulam, Pedda Venkat Lingaiah, Boddupally, Shanthan Rao, Pamulaparthy, Narsaiah, Banda, Devi Allanki, Aparna, Singh Sijwali, Puran |
| Zdroj: |
Letters in Drug Design & Discovery; June 2015, Vol. 12 Issue: 5 p393-407, 15p |
| Abstrakt: |
A series of novel fluorinated heterocyclic hybrid molecules based on triazole & quinoxaline scaffold were designed, synthesized and evaluated for inhibition of Plasmodium falciparum, a virulent human malaria parasite. Mono and bis triazole tagged quinoxaline analogs were synthesized by propargylation of 6-amino quinoxaline followed by click reaction with various substituted aromatic azides under uncertain reaction conditions. The newly synthesized molecules were assessed for antimalarial activity and three of the analogs were identified as promising leads which killed parasites with IC50 values <10 μM and showed 27-70 selective indices. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
