| Abstrakt: |
The histological, electron microscopic, and immunological findings in a case of eccrine porocarcinoma are described. The tumors were verrucous, wart‐like lesions and nodules which ulcerated secondarily. They were located on the leg. The patient died in a few months from dissemination of the disease. The tumor examined was epidermotropic and mainly composed of a clear cell proliferation. Ultrastructurally, the cells showed large, nucleolated nuclei, numerous mitochondria, dilated endoplasmic reticulum, single desmosomal plaques, sparse tonofibrils in the perinuclear region, multivesicular dense bodies, and interdigitating cytomembranes. A few dark cells were present. No Langerhans cells, indeterminate dendritic cells or melanocytes were observed. The tumor cells were labeled with KL 1 monoclonal antikeratin antibody. The secretory cells of uninvolved eccrine sweat glands in the close vicinity of the tumor and in the perilesional skin were strongly labeled with D 47 monoclonal antibody reacting with the secretory cells of human eccrine sweat gland, whereas the tumor cells remained unlabeled. Our study results showed that the origin of this tumor was not the secretory portion of the gland but rather its excretory portion. |
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