| Autor: |
Daniels, Helena M., O'Toole, Alison, Hussein, Munther J., Corridori, Sergio, Alexander, Graeme J.M., Williams, Roger |
| Zdroj: |
Journal of Hepatology; January 1994, Vol. 20 Issue: 3 p370-375, 6p |
| Abstrakt: |
A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infection, we have examined the effects of a thymic hormone (THFγ2) on peripheral blood mononuclear cells from patients with chronic hepatitis B virus infection. THFγ2 (50 or 150 ng/ml) alone was without effect; in the presence of low doses of the mitogen phytohaemagglutinin, it had a broad effect in patients and controls. The effect on interleukin-2 production was greater in patients than controls with a significant increase in production at 150 ng/ml for patients alone (p=0.037). Tumour necrosis factor αproduction was enhanced in all patients and controls, with a greater effect seen at 150 ng/ml THFγ2 than 50 ng/ml. There was no effect on interferon γproduction or on the expression of membrane markers of T-cell activation. THFγ2 has substantial immunomodulatory activity in chronic hepatitis B virus carriers and in vivoassessment of THFγ2 in chronic hepatitis B virus is indicated. |
| Databáze: |
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