| Autor: |
Rossin, R, Blok, D, Visentin, R, Feitsma, R.I.J, Giron, M.C, Pauwels, E.K.J, Mazzi, U |
| Zdroj: |
Nuclear Medicine and Biology; October 2001, Vol. 28 Issue: 7 p865-873, 9p |
| Abstrakt: |
99mTc-labeling studies have been performed on CCK4fragment of cholecystokinin, starting from 99mTc-pertechnetate, by using tin(II)pyrophosphate or tin(II)gluconate as reducing agents, together with NaBH4acting as a stabilizing agent of tin(II). Gluconate has been used as exchange ligand in the carrier addedexperiments and in the syntheses of 99Tc-CCK4and Re-CCK4complexes to be able to reproduce at macroscopic level the same chemical reactions occurring at non carrier addedconditions. 99mTc-labeling yields higher than 95% have been achieved depending on Sn(II) concentration, CCK4/gluconate ratio, reaction time and applied temperature. The species produced with 99mTc, 99Tc, and cold rhenium nuclides have been compared by means of HPLC measurements, which showed similar retention times and thus probably the same species in the three situations. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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