| Autor: |
Menzies, Barbara E., Kourteva, Iordanka |
| Zdroj: |
FEMS Immunology and Medical Microbiology; September 2000, Vol. 29 Issue: 1 p39-39, 1p |
| Abstrakt: |
The internalization of Staphylococcus aureus by cultured human umbilical vein endothelial cells was recently shown to induce apoptosis. We examined the role of a-Toxin, a major pore-forming toxin secreted by S. aureus, in causing apoptosis in vitro. Purified a-Toxin, at sublytic concentrations, induced apoptosis in endothelial cell monolayers. Comparisons of two a-Toxin (hla)-positive S. aureus strains and their isogenic hla-deficient mutants in the invasion assay of endothelial cells demonstrated that the capacity to produce a-Toxin was associated with a greater propensity for apoptosis in endothelial cells. These results demonstrate for the first time that expression of a-Toxin during endothelial cell invasion by S. aureus enhances apoptosis. |
| Databáze: |
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