| Autor: |
Baker, Christopher T., Salituro, Francesco G., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Schairer, Wayne C., Tung, Roger D. |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; 1998, Vol. 8 Issue: 24 p3631-3636, 6p |
| Abstrakt: |
A combination of structure-based design and both solution, and solid-phase synthesis were utilized to derive a potent (nM) series of HIV-1 protease inhibitors bearing a structurally novel backbone. Detailed structural analysis of several inhibitors prepared in this series has suggested that rigidification of the P1/P2 region of this class of molecules may result in compounds with improved potency. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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