| Autor: |
Guzaev, Andrei, Manoharan, Muthiah |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; 1998, Vol. 8 Issue: 24 p3671-3676, 6p |
| Abstrakt: |
A novel method for the preparation of oligonucleotides conjugated with nucleophilic ligands is described. A new phosphoramidite building block derived from N-chloroacetyl-6-aminohexanol is attached at the 5′-terminus on the last step of oligonucleotide synthesis. Postsynthetic treatment of support-bound modified oligonucleotide with a variety of amines and mercaptans affords conjugates in high yield. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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