| Autor: |
Ambler, John, Baker, Emma, Brown, Lyndon, Butler, Paul, Farr, Dave, Dunnet, Karen, Grand, Darren Le, Janus, Diana, Jones, Darryl, Menear, Keith, Mercer, Mark, Smith, Garrick, Talbot, Mark, Tweed, Morris |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; 1998, Vol. 8 Issue: 24 p3583-3588, 6p |
| Abstrakt: |
The chemical optimisation of CGH1668 1 is described employing an in vivo model of absorption to determine the influence on bioavailability of single point modifications to five key molecular templates. The discovery of an orally bioavailable and selective thrombin inhibitor, 24, highlights the utility of this approach. |
| Databáze: |
Supplemental Index |
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