In the Search for New Anticancer Drugs, XVI Selective Protection and Deprotection of Primary Amino Groups in Spermine, Spermidine and Other Polyamines

Autor: Sosnovsky, George, Lukszo, Jan
Zdroj: Zeitschrift für Naturforschung B; January 1986, Vol. 41 Issue: 1 p122-129, 8p
Abstrakt: Spermidine, spermine and other polyamines 1-5 were selectively protected at the terminal primary amino functions without affecting the secondary amino groups using N-ethoxycarbonyl-phthalimide (15), the Nefkens’ reagent. Three representative products, 17, 18 and 20, readily underwent acylation at the secondary amino nitrogen to give the corresponding compounds 21-26. Selective deprotection of two representative samples 22 and 25 at the primary amino function by hydrazinolysis yielded the corresponding derivatives 27 and 28 with free primary amino groups.
Databáze: Supplemental Index