Immunoprotective Effect of Cu/Zn Superoxide Dismutase on Myeloid Graffi Tumor-Bearing Hamsters

Autor: Toshkova, Reneta A., Dimitrova, Petia A., Ivanova, Emilia H., Dolashka, Pavlina A., Angelova, Maria B., Pashova, Svetlana B., Slokoska, Ludmila S., Voelter, Wolfgang
Zdroj: Zeitschrift für Naturforschung C; August 2000, Vol. 55 Issue: 7-8 p649-656, 8p
Abstrakt: Investigation on the immunoprotective activity of Cu/Zn superoxide dismutase from Humicola lutea 103 AL (HLSOD) in hamsters with transplanted myeloid tumor was performed. Survivability, tumor growth and tumor transplantability were followed. The immune status of tumor-bearing animals, injected with the optimal protective HLSOD dose, was examined during 27 days after tumor transplantation by the following parameters: (i) the number, migration and phagocytic activity of peritoneal macrophages, (ii) the phagocytic activity of blood polymorphonuclear leukocytes (PMNs), (iii) the responsibility in vitro of spleen lymphocytes to T and B cell mitogens.
Databáze: Supplemental Index