Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2creceptor agonist with selectivity over the 5-HT2areceptor: potential therapeutic applications for epilepsy and obesity

Autor: Isaac, Methvin, Slassi, Abdelmalik, O'Brien, Anne, Edwards, Louise, MacLean, Neil, Bueschkens, Donna, Lee, David K.H, McCallum, Kirk, Lannoy, Ines De, Demchyshyn, Lidia, Kamboj, Rajender
Zdroj: Bioorganic & Medicinal Chemistry Letters; May 2000, Vol. 10 Issue: 9 p919-921, 3p
Abstrakt: A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2cand 5-HT2a, receptors and found to be agonists at 5-HT2cwith selectivity over 5-HT2a.
Databáze: Supplemental Index