| Autor: |
Peyman, Anusch, Wehner, Volkmar, Knolle, Jochen, Stilz, Hans Ulrich, Breipohl, Gerhard, Scheunemann, Karl-Heinz, Carniato, Denis, Ruxer, Jean-Marie, Gourvest, Jean-Francois, Gadek, Thomas R, Bodary, Sarah |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; January 2000, Vol. 10 Issue: 2 p179-182, 4p |
| Abstrakt: |
The synthesis of a series of RGD mimetic αVβ3antagonists containing a hydantoin scaffold is shown. The results demonstrate some of the structural requirements for the design of selective αVβ3antagonists (vs αIIbβ3) in terms of the Arg-mimetic, the distance between N- and C-terminus and the lipophilic side chain. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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