In the Search for New Anticancer Drugs, I Antitumor Activity of Various Nitroxyl- and Aziridine-Containing Phosphorus Compounds

Autor: Konieczny, Maria, Sosnovsky, George, Gutierrez, Peter
Zdroj: Zeitschrift für Naturforschung B; July 1981, Vol. 36 Issue: 7 p888-891, 4p
Abstrakt: A series of pentavalent phosphorus compounds containing the nitroxyl and/or aziridinyl moieties was evaluated for antitumor activity against P 388 and L 1210 lymphocytic leukemias, and compared to the clinical agent thio-TEPA (1). The compounds with the structures 5-13 were found to be active, with a T/C value greater than 125. The percent ILS was also determined.
Databáze: Supplemental Index