Immunologische Studien am Omentum V

Autor: Krüsmann, W. F., Kasemir, H., Ax, W., Fischer, H.
Zdroj: Zeitschrift für Naturforschung B; October 1970, Vol. 25 Issue: 10 p1160-1163, 4p
Abstrakt: Neonatally thymectomized mice show a markedly reduced mesothelial proliferation following an antigenic stimulus. As thymectomy causes a drastic reduction of circulating lymphocytes, lymphopenia may be the cause of the reduced mitotic rate of mesothelial cells. In order to prove this hypothesis, lymphopenia was caused by a) drainage of the thoracic duct and b) by injection of anti-thymocyte serum. In both types of experiments a drastic reduction of mesothelial proliferation was observed showing good correlation with the degree of lymphopenia. These results indicate that lymphocytes of thymic origin release mitosis promoting factors and thereby contribute to an immune response.
Databáze: Supplemental Index