Synthesis of Some New (Na-Dipicolinoyl)-bis-L-leucyl-DL-norvalyl Linear tetra and Cyclic octa Bridged Peptides as New Antiinflammatory Agents
| Autor: | Abo-Ghalia, Mohamed H., Amr, Abd El-Galil E., Abdalah, Mohamed M. |
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| Zdroj: | Zeitschrift für Naturforschung B; September 2003, Vol. 58 Issue: 9 p903-910, 8p |
| Abstrakt: | In continuation to our search for new amino acid and peptide based anti-inflammatory agents, the suggestion, synthesis, structure elucidation of some Na-bis-dipicolinoyl amino acids, linear tetra and cyclic octa bridged peptides 1-9, of which four are new compounds 6-9, were herein realized. Accordingly, Na-bis-dipicolinoyl-L-leucine methyl ester 1, the corresponding acid 2, its bis-DL-norvalyl methyl ester homologue 3, the acid 4 and hydrazide 5 analogues were conventionally prepared. |
| Databáze: | Supplemental Index |
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