| Autor: |
GuhaThakurta, D, Stormo, G D |
| Zdroj: |
Bioinformatics; July 2001, Vol. 17 Issue: 7 p608-621, 14p |
| Abstrakt: |
Transcriptional activation in eukaryotic organisms normally requires combinatorial interactions of multiple transcription factors. Though several methods exist for identification of individual protein binding site patterns in DNA sequences, there are few methods for discovery of binding site patterns for cooperatively acting factors. Here we present an algorithm, Co-Bind (for COperative BINDing), for discovering DNA target sites for cooperatively acting transcription factors. The method utilizes a Gibbs sampling strategy to model the cooperativity between two transcription factors and defines position weight matrices for the binding sites. Sequences from both the training set and the entire genome are taken into account, in order to discriminate against commonly occurring patterns in the genome, and produce patterns which are significant only in the training set. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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