| Autor: |
Coste, André, Millepied, Marie-Claude, Chapelin, Catherine, Reinert, Philippe, Poron, Françoise, Boucherat, Michel, Escudier, Estelle |
| Zdroj: |
Annals of Otology, Rhinology & Laryngology; October 1997, Vol. 106 Issue: 10 p854-858, 5p |
| Abstrakt: |
The goal of the study was to evaluate the incidence of primary ciliary dyskinesia (PCD) in children suffering from recurrent respiratory tract infections (RRIs) by means of a noninvasive method. Respiratory ciliated cells were collected by nasal brushing in 118 children (4.6 ± 2.5 years) with RRIs. The ciliary beat frequency (CBF) was measured with a stroboscopic method, and when the CBF was abnormal, the ciliary ultrastructure was analyzed by a quantitative method. The CBF could be measured in 106 patients (90%) and was abnormal in 15 patients. The ciliary ultrastructure was found to be abnormal in 11 of 15 patients: PCD was diagnosed in 6 cases, and acquired ciliary defects were observed in the remaining 5 patients. Our conclusion, that PCD is rare but not exceptional (5.6%) in children with RRIs, justifies the systematic investigation of ciliated cells in such patients. For this purpose, nasal brushing can be used to sample ciliated cells even in young children. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
