Development of chronic secondary epileptic foci following intrahippocampal injection of tetanus toxin in the rat
Autor: | Jefferys, JG, Empson, RM |
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Zdroj: | Experimental Physiology; September 1990, Vol. 75 Issue: 5 p733-736, 4p |
Abstrakt: | It is known that injecting a minute dose of tetanus toxin into rat hippocampus leads to a chronic epileptic syndrome. Here we describe the development of secondary, ‘mirror’ epileptic foci in the hippocampus contralateral to a single injection of the toxin (12 mouse LD50). This was detected in slices in vitro prepared 6 to 56 days after injection, both as evoked after‐discharges and as spontaneous synchronous bursts that were mainly restricted to subregions CA3b and c. |
Databáze: | Supplemental Index |
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