| Autor: |
Wilde, CJ, Kerr, MA, Calvert, DT |
| Zdroj: |
Experimental Physiology; July 1991, Vol. 76 Issue: 4 p533-537, 5p |
| Abstrakt: |
Degradation of newly synthesized casein in rat mammary gland perfused in situ was measured by a pulse‐chase method using [3H]proline. Casein degradation during secretion was observed in the absence of prolactin, but not with prolactin present. Partial inhibition by chloroquine showed that hormone‐dependent degradation occurred intracellularly by a lysosomal mechanism. The study indicates that this post‐translational mechanism is a physiological regulator of net casein secretion. |
| Databáze: |
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