| Autor: |
Breen, Thomas R., Chinwalla, Vandana, Harte, Peter J. |
| Zdroj: |
Mechanisms of Development; July 1995, Vol. 52 Issue: 1 p89-98, 10p |
| Abstrakt: |
We show that maintenance but not initiation of engrailed (en)gene expression in the Drosophilaembryo requires trithorax (trx), which is also required to maintain stable long-term expression of the homeotic genes throughout development. Like the homeotic genes, enexpression is dependent on trxin only a subset of embryonic cells normally expressing en, including specific cells in the nervous system and the dorsal fat body cells surrounding the gonad. Loss of enexpression in the dorsal fat body is correlated with the sterility of enfemales which also carry trxmutations. In addition, trxis required for normal enexpression in the posterior compartment of the developing wing, reflected in enhancement of enphenotypes in enadults which also carry trxmutations. trxappears to be dispensable for maintenance of enexpression in other embryonic cells. The trxprotein binds to the region of the polytene chromosomes which contains the engene, suggesting that trxregulates enexpression directly by binding to the enregulatory region. |
| Databáze: |
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