| Abstrakt: |
In mice, the Kit receptor tyrosine kinase and its ligand, Steel factor, are required for melanogenesis, hematopoesis and gametogenesis We have identified a Xenopusgene, Xkl-1(XenopusKit-like-1) whose predicted protein has striking sequence identity in the catalytic domain and kinase insert to that of c-kit. Xkl-1is expressed only in dorsal tissues such as the nervous system, notochord and somites of neurulae. Ultraviolet irradiated embryos and animal caps treated with basic FGF unexpectedly express Xkl-1, since they are considered to develop only ventral type tissues. These observations raise the hypothesis that Xkl-1is involved in Xenopusdorsal development and that dorsal tissues inhibit the expression of Xkl-1in ventral structures. |
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