| Autor: |
Barbosa, Lilian C., Furtado, Ricardo A., Bertanha, Humberto C. C., Tomazella, Iara M., Costa, Eveline S., Bastos, Jairo K., Silva, Márcio L. Andrade e, Tavares, Denise C. |
| Zdroj: |
Journal of Natural Products; October 2014, Vol. 77 Issue: 10 p2312-2315, 4p |
| Abstrakt: |
(−)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (−)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4–5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay. |
| Databáze: |
Supplemental Index |
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