| Autor: |
Bautista-Garfias, C.R., Ixta-Rodríguez, O., Martínez-Gómez, F., López, M.G., Aguilar-Figueroa, B.R., Bautista-Garfias, C.R., Ixta-Rodríguez, O., Martínez-Gómez, F., López, M.G., Aguilar-Figueroa, B.R. |
| Zdroj: |
Parasite - Journal de la Société Française de Parasitologie; March 2001, Vol. 8 Issue: 1 pS226-S228, 3p |
| Abstrakt: |
The capacity of viable, dead Lactobacillus caseiand supernantant from L caseiculture, administered by oral route, to induce resistance in mice against Trichinella spiralisinfection was evaluated. The percentage of adult worm reduction in the intestine five days after T. spiralisinfection as compared with the worm burden in the control group fluctuated between between 53.1 and 58 % in mice treated with viable L. casei, while reductions in animals treated with dead lactobacilli or supernatant from L. caseiculture were of 44 and 32.5 % respectively. The percentage of larvae per gram of muscle tissue reductions, as compared with controls, obtained 30 days after infection ranged from 48.4 to 70.7 % in rodents which ingested viable L. caseicompared with the percentage reductions of 6 5 .9 and 24 % obtained respectively in mice treated with dead lactobacilli or with L. caseisupernatant. The protective response observed in the present study may be explained on the basis of 1) lactobacilli colonization of the intestine, 2) macrophage processing of dead lactobacilli in local immune tissues and presentation of L. casei antigens to Th 1 cells which, in turn, produced IL-2 to activate B cells and other T cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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