| Autor: |
Liance, M., Ricard-Blum, S., Emery, I., Houin, R., Vuitton, D.A., Liance, M., Ricard-Blum, S., Emery, I., Houin, R., Vuitton, D.A. |
| Zdroj: |
Parasite - Journal de la Société Française de Parasitologie; September 1998, Vol. 5 Issue: 3 p231-237, 7p |
| Abstrakt: |
As no antiparasitic drug is definitively efficient in patients with alveolar echinococcosis, the effects of exogenous IFN-γ on murine Echinococcus multilocularisinfection were assessed with regards to the parasite burden, parasite-specific immune responses, and the urinary level of the collagen cross-link pyridinolines. They were analyzed after 3-week treatments with 1 or 5 ug of IFN-γ per day twice a week. The treatment with 1 μg transiently reduced the liver metacestode load, and the metastase weight as far as 6 weeks after the end of treatment. It slightly increased Th 1-type T cell responses and reduced the excretion of pyridinolines. These results should encourage further study to assess whether the decrease in liver fibrosis leads to an improvement of the efficacy of albendazole therapy. In contrast, the treatment with 5 μg increased the liver metacestode load and was less efficient than that with 1 µg in decreasing pyridinoline excretion. These results incitate to follow up carefully patients with alveolar echinococcosis who are treated with IFN-γ. |
| Databáze: |
Supplemental Index |
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