| Autor: |
Bron, Alain M., Pechinot, Andre P., Garcher, Catherine P., Guyonnet, Guy A., Kazmierczak, Antoine M., Schott, Daniela A., Lecoeur, Herve |
| Zdroj: |
American Journal of Ophthalmology; March 1994, Vol. 117 Issue: 3 p322-327, 6p |
| Abstrakt: |
The penetration of sparfloxacin into the aqueous humor after oral administration was studied in 28 patients undergoing cataract surgery. Each patient received a single, oral dose of 400 mg of sparfloxacin. In eight other patients scheduled to undergo vitreal surgery, multiple daily oral doses were administered for a total amount of 1,000 mg. The aqueous levels were (mean ± SEM) 0.127 ± 0.036 μg/ml to 0.404 ± 0.159 μg/ml from two to 24 hours after ingestion. In the vitreous, the mean drug level was 0.840 μg/ml (range, 0.480 to 2.060 μg/ml), from 4.3 to 8.0 hours after the most recent oral dose. Blood samples obtained at the same time as vitreous and aqueous taps were assayed by high-performance liquid chromatography. These data demonstrate that therapeutic levels of sparfloxacin may be achieved in noninflamed, noninfected eyes undergoing cataract or vitreous surgery. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
