| Autor: |
Lin, Robert, Holland, Gary N., Helm, Craig J., Elias, Samuel J., Berlin, O. George W., Bruckner, David A. |
| Zdroj: |
American Journal of Ophthalmology; May 1994, Vol. 117 Issue: 5 p657-662, 6p |
| Abstrakt: |
Mycobacterium fortuitumand M. chelonaeare the two most common causes of nontuberculous mycobacterial keratitis, and they may be difficult to differentiate at diagnosis. Mycobacterium fortuitumis generally more sensitive to ciprofloxacin in vitro than is M. chelonae.Using a rabbit model, we compared the efficacy of topical ciprofloxacin (3 mg/ml) against M. chelonaekeratitis to its efficacy against M. fortuitumkeratitis. After four days of therapy, ciprofloxacin significantly reduced the number of both organisms in treated eyes compared to untreated control eyes (both P values < .001). Mean culture ratios (colony-forming units in treated eye divided by colony-forming units in untreated eye for each rabbit) were used to compare efficacy between groups. When all treated animals were considered, no significant difference was found between groups (P = .13). When outlier values were excluded, ciprofloxacin was more effective against M. fortuitumthan M. chelonae(P = .01). When treated and untreated eyes were compared after therapy in the M. fortuitumgroup, ciprofloxacin treatment was associated with a reduction in mean stromal infiltrate area (P = .03) and in the tendency to form satellite lesions (P = .07). A clinical effect was not observed in the M. chelonaegroup. Although ciprofloxacin is effective against both organisms, it appears to be less effective against M. chelonaethan M. fortuitumin vivo. |
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