Trabeculectomy, Phacoemulsification, and Posterior Chamber Lens Implantation With and Without 5-Fluorouracil

Autor: O'Grady, John M., Juzych, Mark S., Shin, Dong H., Lemon, Lance C., Swendris, Ronald P.
Zdroj: American Journal of Ophthalmology; November 1993, Vol. 116 Issue: 5 p594-599, 6p
Abstrakt: Subconjunctival 5-fluorouracil has been an effective adjunct in glaucoma filtering surgery. We investigated the effectiveness of 5-fluorouracil in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation (glaucoma triple procedure). Seventy-four patients were enrolled and randomly assigned into two groups to receive either no 5-fluorouracil (control patients) or low-dose 5-fluorouracil (mean total dose, 24.8 mg; mean number of injections, 5.0 ± 1.3). The mean preoperative intraocular pressure was 20.1 ± 5.4 mm Hg for the 5-fluorouracil group and 21.0 ± 5.2 mm Hg for the control group (P = .48, Student's unpaired t-test). The mean number of medications was 2.2 ± 1.0 and 2.0 ± 1.0 (P = .49, Mann Whitney U test), respectively.
Databáze: Supplemental Index