| Autor: |
Straatsma, Bradley R., Horwitz, Joseph, Takemoto, Larry J., Lightfoot, David O., Ding, Lin-Lin |
| Zdroj: |
American Journal of Ophthalmology; April 1984, Vol. 97 Issue: 4 p457-469, 13p |
| Abstrakt: |
In a series of 50 consecutive adult patients (24 men and 26 women) we studied aging-related cataract by means of comprehensive presurgical examination of the patient, the eyes, and the cataractous lens; cataract sample collection from predetermined sites during surgery; biochemical analyses with high-performance liquid chromatography of each individual lens sample; and computer-assisted biostatistical data analysis. Compared with normal values established on clear human lenses obtained from a donor eye program, the ratios of 23,000 (23K) crystallin to total beta, gamma, and low molecular weight soluble proteins were statistically significantly lower in the anterior axial lens cortex (P < .001) and in the lens nucleus (P < .001). Increased grades of cortex opacification and nucleus opacification were generally associated with progressively decreased 23K crystallin ratios. In this series of patients with diverse cataract-associated systemic diseases, family histories, ophthalmic disorders, and drug-use patterns, decreased 23K crystallin ratios were a sensitive marker for aging-related cataract. Similar biochemical abnormalities in patients with multiple cataract-associated factors may have important clinical implications. |
| Databáze: |
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