| Autor: |
Machado, Rachel R.P., Jardim, Deborah F., Souza, Andrezza R., Scio, Elita, Fabri, Rodrigo L., Carpanez, Arthur G., Grazul, Richard M., de Mendonça, José Paulo R.F., Lesche, Bernhard, Aarestrup, Fernando M. |
| Zdroj: |
Revista Brasileira de Farmacognosia; May-June 2013, Vol. 23 Issue: 3 p488-496, 9p |
| Abstrakt: |
The anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini(L.) Skeels, Myrtaceae, leaves was investigated in vivo. The antiinflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. boviswas detected in vitroby an interferometric method in liquid culture medium. The chemical constituents of the essential oil were determined by GC/MS. Higher yields of the essential oil of S. cuminileaves were obtained by extraction in a Clevenger apparatus when the fresh leaves were previously frozen as a pre-processing step. The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system. |
| Databáze: |
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