| Autor: |
Aguirre, F., Martin, I., Grinspon, D., Ruiz, M., Hager, A., De Paoli, T., Ihlo, J., Farach, H.A., Poole, C.P. |
| Zdroj: |
Free Radical Biology & Medicine; March 1998, Vol. 24 Issue: 4 p580-585, 6p |
| Abstrakt: |
A study of oxidative damage was made in elderly noninsulin-dependent diabetes mellitus (NIDDM) patients. A statistically significant increase in glucose and fructosamine was found in fasting NIDDM patients, as well as an increase in the oxidation induced by tert-butyl hydroperoxide. The Total Reactive Antioxidant Potential (TRAP) of the plasma was much reduced (p< .02) and the uricemia was unchanged. The erythrocytes of diabetic patients show greater basal oxidation products (p< .05), and the susceptibility of the diabetic erythrocytes to oxidation injury was also shown to increase in the oxidation induced by t-BOOH (p< .05). Linear regression studies showed that TRAP was associated directly with uric acid (p< .05) and inversely with fructosamine and with glucose (p< .03 and p< .05 respectively) in patients with NIDDM, but not in the controls. The levels of fructosamine were found to be related to the basal damage of the red blood cells (direct correlation, p< .001). This study suggest an useful approach to diabetic oxidative stress for clinical settings. |
| Databáze: |
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