| Autor: |
Meyer, Alison E., Gatza, Catherine E., How, Tam, Starr, Mark, Nixon, Andrew B., Blobe, Gerard C. |
| Zdroj: |
Molecular Biology of the Cell; August 2014, Vol. 25 Issue: 15 p2291-2304, 14p |
| Abstrakt: |
TβRIII is basolaterally localized in polarized breast epithelial cells. The disruption of TβRIII targeting by mutation of proline 826 results in global loss of cell polarity through enhanced EMT. The mistargeting of TβRIII results in enhanced proliferation, migration, and invasion in vitro and enhanced tumor formation and invasion in vivo. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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