β-Agarofurans and Sesquiterpene Pyridine Alkaloids from Maytenus spinosa

Autor: Gutiérrez-Nicolás, Fátima, Oberti, Juan C., Ravelo, Ángel G., Estévez-Braun, Ana
Zdroj: Journal of Natural Products; August 2014, Vol. 77 Issue: 8 p1853-1863, 11p
Abstrakt: Nine new β-dihydroagarofurans (1–9) and four new sesquiterpene pyridine alkaloids (10–13) were isolated from the leaves of Maytenus spinosa. Their structures were determined mainly by 1D- and 2D-NMR spectroscopic studies. The absolute configuration of compound 6was established using CD spectroscopy. Several derivatives (14–20) were prepared from the sesquiterpene 13. Most of the sesquiterpenoids were tested for anti-HIV activity, but only compound 1was found to be active.
Databáze: Supplemental Index