| Autor: |
E. McPherson, S., D. Kuratani, J., L. Cummings, J., Shih, J., S. Mischel, P., V. Vinters, H. |
| Zdroj: |
Behavioural Neurology; 1994, Vol. 7 Issue: 1 |
| Abstrakt: |
Aphasia is a common manifestation of Creutzfeldt-Jakob disease (CJD), and investigation of the linguistic disorders of CJD patients may provide insights into the neurobiological mechanisms of language and aphasia. We report an autopsy-confirmed case of CJD in which the presenting symptom was change in language abilities. The patient ultimately evidenced mixed transcortical aphasia (MTA) with echolalia. Disruption of frontal-subcortical circuits with environmental dependency accounts for the symptoms in MTA, including intact repetition and echolalia. Observation in this patient and a review of the literature suggest that frontal-subcortical circuit dysfunction may contribute to the syndrome of echolalia. This hypothesis offers an alternative explanation to “isolation” of the speech area as the cause of MTA. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text