| Autor: |
Vorperian, Vicken R., Zhou, Zhengfeng, Mohammad, Saeed, Hoon, Timothy J., Studenik, Christian, January, Craig T. |
| Zdroj: |
Journal of the American College of Cardiology; November 1996, Vol. 28 Issue: 6 p1556-1561, 6p |
| Abstrakt: |
Objectives. Proarrhythmic effects have been observed with the selective histamine1(H1) receptor antagonist drug astemizole, a widely prescribed antihistamine. The metabolites of astemizole and those of other antihistamine compounds have not been implicated as causative agents of cardiac arrhythmias. The purpose of this study was to examine whether desmethylastemizole, the principal metabolite of astemizole, blocks delayed rectifier potassium (K+) channels. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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