| Autor: |
INYUSHKINA, Yuliya V., BULGAKOV, Victor P., VESELOVA, Marina V., BRYUKHANOV, Valery M., ZVEREV, Yakov F., LAMPATOV, Vyacheslav V., AZAROVA, Olga V., TCHERNODED, Galina K., FEDOREYEV, Sergey A., ZHURAVLEV, Yury N. |
| Zdroj: |
Bioscience, Biotechnology, and Biochemistry; May 2007, Vol. 71 Issue: 5 p1286-1293, 8p |
| Abstrakt: |
During an investigation of plant cell cultures that might be useful in the treatment of renal disorders, we established a vigorously-growing E-4 callus culture of Eritrichium sericeumthat produced large amounts of caffeic acid metabolites, (−)-rabdosiin (1.8% dry wt) and rosmarinic acid (4.6% dry wt). Elicitation of the calli by methyl jasmonate induced a 38% increase in total polyphenol production. The most efficient method of eliciting (−)-rabdosiin biosynthesis was through the treatment of E-4 calli with cuprum glycerate, which induced an increase in (−)-rabdosiin production of as much as 4.1% dry wt. Oral administration of E-4 callus biomass (100 mg/kg/d for 30 d) to rats with induced Masugi-nephritis caused an increase in diuresis and lowered creatinine excretion and proteinuria levels as compared with Masugi-nephritis untreated rats. While all of the Masugi-nephritis untreated rats began to suffer, near a quarter of the E-4 treated rats remained in good health. This result indicates that the E-4 culture has the potential to alleviate the symptoms associated with nephritis. |
| Databáze: |
Supplemental Index |
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