Serum thyroid hormone concentrations and weight loss relationships in eight obese women during semistarvation

Autor: Adami, Silvano, Ferrari, M., Galvanini, G., Cominacini, L., Bruni, F., Pelloso, M., Cascio, V.
Zdroj: Journal of Endocrinological Investigation; July 1979, Vol. 2 Issue: 3 p271-274, 4p
Abstrakt: Eight obese female patients were studied over a period of 15 days whilst on 300 kcal diet. Serum levels of thyroxine and free thyroxine index were not altered significantly by semistarvation. A TRH test performed before and after the diet showed no appreciable change. Weight loss was initially rapid but later slowed despite good patients compliance. Serum concentrations of T3and reverse T3(rT3) early decreased (p<0.01) and increased (p<0.05) respectively, but returned towards control levels even before discontinuation of semistarvation. There was a positive correlation between the percentage decrease in body weight and the percentage increase in serum rT3(p<0.001), and a negative correlation between decrease in body weight and decrease in serum T3(p<0.001). Our results do not suggest that the variations in serum triiodothyronines limit the weight loss; it is probable, on the contrary, that the weight loss promotes the observed variations in thyroid hormones by as yet unknown adaptive metabolic forces.
Databáze: Supplemental Index
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