| Autor: |
Müller, Konstantin H., Spoden, Gilles A., Scheffer, Konstanze D., Brunnhöfer, Regina, De Brabander, Jef K., Maier, Martin E., Florin, Luise, Muller, Claude P. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; February 2014, Vol. 58 Issue: 5 p2905-2911, 7p |
| Abstrakt: |
ABSTRACTSeveral viruses, including human papillomaviruses, depend on endosomal acidification for successful infection. Hence, the multisubunit enzyme vacuolar ATPase (V-ATPase), which is mainly responsible for endosome acidification in the cell, represents an attractive target for antiviral strategies. In the present study, we show that V-ATPase is required for human papillomavirus (HPV) infection and that uncoating/disassembly but not endocytosis is affected by V-ATPase inhibition. The infection inhibitory potencies of saliphenylhalamide, a proven V-ATPase inhibitor, and its derivatives, as well as those of other V-ATPase inhibitors, were analyzed on different HPV types in relevant cell lines. Variation in the selectivity indices among V-ATPase inhibitors was high, while variation for the same inhibitor against different HPV subtypes was low, indicating that broad-spectrum anti-HPV activity can be provided. |
| Databáze: |
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